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KMID : 0613820100200030444
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Journal of Life Science
2010 Volume.20 No. 3 p.444 ~ p.452
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The Effects of Treadmill Exercise on Cognitive Performance, Brain Mitochondrial Aβ-42, Cytochrome c, SOD-1, 2 and Sirt-3 Protein Expression in Mutant (N141I) Presenilin-2 Transgenic Mice of Alzheimer’s Disease
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Koo Jung-Hoon
Eum Hyun-Sub
Kang Eun-Bum
Kwon In-Su
Yeom Dong-Cheol
An Gil-Young
Oh Yoo-Sung
Baik Young-Soo
Cho In-Ho
Cho Joon-Yong
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Abstract
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The purpose of this study was to investigate the effects of treadmill exercise on Aβ-42, cytochrome c, SOD-1, 2 and Sirt-3 protein expressions in brain cytosol and mitochondria in mutant (N141I) presenilin-2 transgenic mice with Alzheimer’s disease (AD). The mice were divided into four groups (Non-Tg-sedentary, n=5; Non-Tg treadmill exercise, n=5; Tg-sedentary, n=5; Tg treadmill exercise, n=5). To evaluate the neuroprotective effect of treadmill exercise, Non-Tg and Tg mice were subjected to exercise training on a treadmill for 12 wk, after which their brain cytosol and mitochondria were evaluated to determine whether any changes in the cognitive performance, Aβ-42 protein, cytochrome c protein, anti-oxidant enzymes (SOD-1, SOD-2) and Sirt-3 protein had occurred. The results indicated that treadmill exercise resulted in amelioration in cognitive deficits of Tg mice. In addition, the expressions of mitochondrial Aβ-42 and cytosolic cytochrome c protein were decreased in the brains of Tg mice after treadmill exercise, whereas antioxidant enzymes, SOD-1 and SOD-2 were significantly increased in response to treadmill exercise. Furthermore, treadmill exercise significantly increased the expression of Sirt-3 protein in Non-Tg and Tg mice. Taken together, these results suggest that treadmill exercise is a simple behavioral intervention which can sufficiently improve cognitive performance and inhibit Aβ-induced oxidative stress in AD.
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KEYWORD
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Alzheimer’s disease (AD), β-amyloid-42 (Aβ-42), anti-oxidant enzyme-1, 2 (SOD-1, 2), silent information regulator-3 (Sirt-3), presenilin-2 (PS-2), treadmill exercise
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